I recently stuck some JJ preamps into my Peavey 5150-II, and the difference from the old tubes was incredible!
The amp tech I got to look over the amp tested the output of the transformer, and found that one side was very much stronger than the other, so my "matched set" of 4 tubes actually meant having 2 running at about 33 mA each and the other 2 running at nearer to 20 mA each.
He was pretty scathing about "matched" tube sets, because, in practice, for almost every amp it's not that crucial - there are other factors which may (or may not!) negate the matchedness of your tubes.
For high gain amps, the other thing he mentioned was that you're really after something with plenty of headroom that's built very well (and will therefore last longer). I had got some Svetlana Winged C 6L6GC tubes, and he suggested that next time I buy the one up in their range, because they're built better.
The pre-amp tubes are far more important for tone in a high-gain, high-output metal amp, like the 120W 5150-II I have.
I bought 4 JJs and 2 Sovtek ECC84lps tubes, and although I haven't tried mixing them around in the pre-amp section, I could do so. As long as you get good quality tubes for both pre- and post- stages, you'll be fine!
Roo