If I wanted SRV tone, I would do like SRV. Get thee an old-skool Strat set up with huge strings, high action, downtuned half-step or whole-step, and low-output vintage style pickups. Apache or MM. That's Number One in a nutshell.
Play through an 808 Tube Screamer or Fuzzface, goosing a dimed vintage Fender tube amp. Get that big, ballsy tone that the revolutionary working masses love so well.