gWem seems to be the man on flying Vs round here, but I have an Explorer, and I've always assumed that they're vaguely similar? Possibly not - maybe there's considerably more wood in an Explorer - shoot me down here gWem :)
Anyway, my Explorer's a whole bunch of mahogany, and accoustically the darkest "round" sounding guitar I have. When I got it, it had Gibson's 500T ceramic pups in, which I quite like, but not what I was after. I was looking for a "blues-machine", possibly similar to what you're after Stringkiller...
I was umming and ah-ing about what sort of BKPs to get and was leaning towards Stormy Mondays. Another possibility was Riff Raffs in my mind, partly because they are roughly the type of pups that Gibson would have been putting in the re-issues in the mid 70s. So, seeing as I had a set in an Epi SG, I thought I'd give them a go temporarily...
They never came out again! - absolutely gorgeous sounding from the moment I plugged it in again. They rock when I want them to and clean up nicely too. I can get really lovely "smooth with a bite" lead tones out of it. And I often find myself playing the Andy Powell "V" parts from Wishbone Ash on it. If I was going to gig again in bluesy set up, with only one guitar, it's probably the Riff-Raffed Explorer I'd take as it's the most versatile of my lot for that kind of gig.
I think if I'd gone for Stormies, I might not have got quite enough raunch when I needed it - but that's just a guess based on others' descriptions of them.
So I'll throw Riff Raffs in the suggestion pot for the bluesier V. :D
For a more modern metal sound... sorry, can't help on that one, I'm afraid.