Like what TO says, it would depend on what I was trying to achieve.
For my usual style of playing, vintage rock sounds and mainly blues, blues/rock, pop, I'd choose Mississippi Queen - without even thinking. It gives me "almost" humbucker but less compressed. Backing off the volume it's definitely a single coil but fat. That would give me the most versatility in a single pup guitar.
However, if I was playing heavier stuff I'd be looking at one of the high output ones, one that cleans up nicely. I seem to remember I've been recommend nailbomb, warpig, and crawler for that sort of thing in the past - but don't quote me, I haven't actually tried them yet! :lol: