ok this is really weird. I was playing along to some backing tracks today, with my guitar through amplitube 2 (plugged into the Inspires hi-z input). The backing track started making that crackly distorted noise thing, but the guitar sounded fine :\ I read that I can disable my onboard audio through the bios, reading the manual that doesnt look hard to do, seems like I just enter setup, go to integrated peripherals then disable the OnChip audio controller. Does that sound about right? I know going into the bios can seriously mess up the system so I dont want to break it, but if that sounds safe I'll give it a go.
Presonus tech support said to make sure the onboard audio is disabled but didnt say whether to do it just in windows or in the bios as well..