I tend to like lighter guitars. It's not a comfort issue for me really; lift some weights and eat some steak and you'll be fine, like Zakk Wylde said (take this with humor :D I know that people who have hurt their back or neck can have painful experiences with heavy guitars like Les Pauls).
Well, back to the weight. Like was said, every piece of wood is different. But in general, when the body is GOOD QUALITY and light in weight, it's easier for the strings to make the wood vibrate. Simple physics. And hence, more of the woods tone is brought out. I believe that is why I usually find the heavy guitars lacking in personality. They don't resonate that well. It's easy to make a lighter guitar feed back in a musical way.
My opinion, once again. And of course, you have to take into account that some wood species are naturally heavier than others, like maple vs. swamp ash.
On the neck, I think stiff and hard woods are the ones to go for.
-Zaned