It's at Exel, isn't it?
Good DLR service but yes, Jubilee line's down at the weekend so only sensible interchange to get on is Bank (as Canary Wharf & Canning Town interchanges are on the Jubilee). Waterloo & City line's good from Waterloo but it doesn't run on Sundays and closes 8ish on Saturday. From the East you can get on at Stratford, South Lewisham/Greenwich (10 mins from London Bridge stn) but otherwise that's it.
PITA, really.
I'm not a talking tube map, honest, I just live out that way & the whole engineering work thing is driving me mad.
As for the strike... DLR isn't usually affected but getting across town is an absolute bitch as everything else is really busy. You can be creative & get a boat from London Bridge/Waterloo to Canary Wharf, then DLR but even that'll have a lot more people travelling on it.