My Blackstar combo tends to buzz at high volumes, but it's not that loud, and not that much of a problem. It's something in the amp circuit that does it I think, and it goes away when i plug it into an extension cabinet.
If it comes back, try taking the rebel off of the cabinet, and see if it goes away.
Why do you think your buzz was around 4200Hz? I'm pretty sure that wouldn't sound like a buzz at all, that'd actually be quite a high note! (A C8 in fact!)