Yes, single-coils are much better for bringing out the subleties of your playing. I've never heard a humbucker guitar that can produce as nice a clean sound as a Strat, Tele or even something with P-90s.
Blues, country, funk, pop, maybe even jazz.... those single-coils knock humbuckers into a c--ked hat.
If you're sitting around at home just quietly noodling, enjoying the sound of a guitar straight into an amp, it's single-coils all the way.
But hold on a moment. Take off your Eric Johnson ears. Just think for a moment what humbuckers can do.
THEY $%ING ROCK.