Up until about 3 months ago I owned the RV50 head and played it through a 2x12 closed back cab.
I have to say, it was one of my favourite amps ever...but wasn't getting used in the end, so sold it to fund a Princeton Reverb for at home.
Anyway, back to the question - significantly different is the answer. I played both and liked the 50 better. It was warmer and rounder, I liked the 6V6s over the EL34s.