:D Hi JP love George Thorogood !!!
A great player, George use`s semi`s loaded with P90`s. i`ve seen him playing through different amps over the years Fender, Marshall, Matchless etc. He likes to drive his amps. If you`ve got a modest gain amp turn the gain up to about 50% [ adjust as you go along ] He`s also Load :P Turn your amp up so that your really pushing it then adjust your gain again to suit. He tends to use open tunnings so this effects the tone he gets i think he tends to use open G tunning more often than not.
Don`t scoop out the middle George has a nice Full sound.
:D 8)