I know there are a thousand topics just like this, but I just can't see digging up 6 month old threads to ask for suggestions.
Playing a 1991 Les Paul Studio into a JCM 800 2203, into an 800 cab with Celestion 65's in it. I use little to no treble in my tone, mids between 6 and 10, and my bass up around 6. Gain is almost ALWAYS higher than it 'needs' to be, but its just my style. I bounce back and forth between playing death metal (see: first two Malevolent Creation albums) and heavier hardcore (think: Integrity, but faster, punkier, and with a hint of thrash). Sometimes a mix of both styles show through in my writing, if that makes any sense. Just a little background to help make a suggestion.
I'm probably picking up a Fender Jaguar Baritone HH shortly, and will be playing the same style and setup.
Thanks to anyone bored enough to help out.