For rhythm:High gain channelLead boost off (will definitely change the tone for more cut)Gain: about 12 – 1 o clockLead Gain about 2-3 o clockBass: about 12 – 1 o clockMid: about 11 o clock, sometimes 2-3 o clock (depending on mood)Treble: about 1 o clockRed MasterRed Presence: 12 o clock with the depth boost pressed in.Voicing: SmoothCountour: Not pressed in (to give the mid spike)Lead:I turn off bypass on my Maxon OD-808 for lead stuffHigh gain channelLead boost onGain: about 12 – 1 o clockLead Gain about 2-3 o clockBass: about 12 – 1 o clockMid: about 11 o clock, sometimes 2-3 o clock (depending on mood)Treble: about 1 o clockGreen MasterGreen Presence 2-3 o clock with the depth boost pressed in.Voicing: rough, sometimes smooth depending on moodCountour: Not pressed in (to give the mid spike)I play mainly metal. My bands songs are pretty all over the place. These pickups and amp seem to do the trick for me; I feel that I can get quite a versitile tone with these pickups.