i think the SLO loop is pretty poorly designed and placed, in a way. It's a cathode follower driving an FX insert, i assume because of the likelihood of driving high impedance bits. The return is a gain stage and a cathode follower driving the tone stack.
I'm sure switching valves for the send or return stages will make a difference, but I don't think it's designed with transparency in mind. As such, I'd wonder just how transparent you can get it since all those stages are always in the signal path for both channels whether you are using effects or not. The driver and the recovery stage are 2 whole 12AX7's, rather than something like the decatone loop which is within 2 triodes of the same valve, which I feel is a situation where changing the valve would make a bigger difference. if that makes sense.
Maybe I'm wrong, but that's my thoughts on it.
what are you using in the loop? maybe it's a buffer making the tone a bit darker?
I wonder if the SLO chassis would take a metroamps loop mounted sideways, or something similar. I know its a lot of work but maybe in a future build it could be worth thinking about. Building the SLO without the loop, then inserting and SS loop between the tone stack and the MV.