Hi,
owning both, and having heard the neck pickup of both sets in the same guitar, I can provide some info.
For SRV and Hendrix, Irish tour would be pretty obvious. It's gritty and pretty bright (depending on the guitar). You won't be able to make them muddy.
Trilogy suite..I wouldn't call them harsh (consider that I have only the neck pickup though). It's darker than the Irish tour, with a thicker and much more modern tone, more mids and output. You mentioned YJM, his Dimarzio pickups at least were pretty low output and on the warm side of tone. That DOD pedal really is a big part of this signal chain.
In your particular case, I'd probably choose the Irish tours. But have a listen to the clips section. They present the differences pretty well!
Btw, you could also consider the slow hands, for a thicker blues tone. Actually, I might just go for those :)
-Zaned