Cheers for all the input & sorry I haven't chipped in again sooner.
For now, I should probably address the guitar to amp signal & the effects loop signal separately. I've used the loop, & consequently the four pedals in it, very little, as it completely kills an already dead guitar tone. For the most part, the loop has been switched out of the circuit completely (I'll get to that shortly).
For the guitar to amp signal, a buffer seems like the best way to go. I'm using quality cable & Voodoo Labs power supplies, so the issue isn't there. It's obviously the eight tb switches that's doing the damage.
I'm going to attempt to build this buffer from the byoc forum:
http://www.buildyourownclone.com/board/viewtopic.php?f=41&t=18652&st=0&sk=t&sd=aI've built a few kits before but perfboard is new to me, so it may be a challenge. I'm going to make it switchable too.
If you use several pedals in conjunction with each other (I only use delay with reverb, for example), you could consider placing them in a single loop/line selector to keep them off the chain until needed.
You may also want to consider a higher output pickup.
I could put the three germanium pedals in a loop - that would take two tb pedals out of the signal when I'm bypassing the fuzz pedals & treble-booster, but add one when I'm not. I guess the MC-401 doesn't need to be there at all, since it's not doing its intended job. I wouldn't consider changing my mules though!
Hunter, how is your GLab switcher for tone-loss, without a buffer? If it has eight switches, does that mean your signal is essentially going through eight true-bypass pedals? If this is the case then I can rule that out. Likewise, I've heard only good things about Lehle. Ultimately, I think I'll get the Sunday Driver, but I'll give the byoc buffer a chance first.
Regarding the Boss pedals; both are buffered, but they're in tb loops as their buffers interfere with the germanium pedals. This way I can take them out of the chain when they're not in use. I guess I could try the compressor first in the chain (in a tb loop) but I think I'm going to go for a dedicated buffer instead.