But, to answer your actual question...
Different sounding amps will make a difference. Different sounding guitars will even make a difference.
In my last band, both me and the other guitar player ran Les Pauls into Marshalls for years. Getting leads to cut through was not evident!
Then he started using a Strat more, and suddenly it became a lot easier. Even easier when he used his Fender Hot Rod Deluxe.
So yes, if you guys use distinctly different guitar tones, you'll find it a lot easier to both be heard.