Yeps,that's "new tubes day".
My HRDx power tubes were dying (stock GT tubes, 6 years old now) and I had some microphonic preamp tube so I ordered a JJ 6V6S pair, two JJ ECC83S (one balanced for the PI) and a JJ 7025 for V1. It was my very first power tube swap and I was a bit worried about the biasing part but the HRDx made it a piece of cake (thanks to the bias test point and bias trim).
Huge improvement wrt/ tone - whether clean, crunch and overdrive - and volume - still freaking loud when you crank it but way more manageable at lower levels, and the transition to overdrive is more progressive. The power amp crunch is way less harsh than it was with the 6L6 - the lows are tighter and more defined, the mids less scooped and the highs a bit smoother yet still sharp - and the drive channel is _way_ better.