The guitar in question has a thinner and much more defined treble end than the typical LesPaul, less mids and more bass. It went through the following pickups: Gibson 500T, Miracle Man, DiMarzio AirZone, Seymour Duncan JB and finally now the Nailbomb.
The Nailbomb fits best in it because it fattens/warms up the treble end and doesn't sound harsh, has healthy mids and is still tight on the lower end. Best of all, it very articulate character make the guitar awesome for leads - as said the guitar is more defined and quicker on the attack on the treble end than typical LesPauls. I particular enjoy the old-school/vintage touch the NB still has a bit, compared to most "metal" pickups.
The Miracle Man had awesome and punishing rhythm sounds, but it didn't fatten/warm up the treble end, which sometimes sounded thin and harsh in standard tuning. I'd choose the MM primarily for warm/dark instruments with a lot of mid range, or downtuned guitars. Overall the MM is more cutting and "in your face", the Nailbomb is more "pushing" and articulate/polite.
The AirZone sounded great, though bassy, but also masked playing mistakes and was just too forgiving. The JB sounded like Lamb Of God in this guitar, but the treble end was thin and harsh.