Hi and welcome here!
Single coils: it depends on the question how woody you want it. I have Mother's Milks and Irish Tours in my two HSS-strats. The MM's are woodier and cleaner, genuine sparkling early sixties-strattones. Instant Frusciante. They're great for blues too. IT's are hotter, grittier, have more bass, less 'bells' then MM's, but clean up very well. I can get close to Frusciante-tones. I would pick IT's for Hendrix-stuff and classic rock.
Humbucker: Pick something that splits well and has enough beef in a strat like a Crawler, Abraxas (a bit more airy and less hot then the Crawler) or even a VHII that does perform very well in strats.
I paired a Crawler with the IT's and a VHII with the MM's. The latter maybe not the obvious combo, but works well and splits good too. The Crawler is fat with a roundend topend, but not dull or lacking treble. Really growls when pushed. Tones above the 12th fret stay ballsy. Cleans up very well and splits very well with the middle-IT. I have it wired the way I can use the full Crawler with the middle-IT or splitted via push-pull.
The VHII is balanced in a strat (enough mids due to the offset coils), great pickup for all kinds of rockmusic, very touchsensitive, articulate, really screams when pushed. Cleans up to a near singlecoil vocal quality. I really love this pickup.
Bottomline: you'll be dead safe with a Crawler/IT's or an Abraxas/IT's or a VHII/IT's combination.
