Which Roadworn? I'm guessing the 60s in sunburst :D
Anyway, I have a 60s with Irish Tours and a 50s that swaps around between Apaches and Sultans.
If it's a 60s, I'd recommend the ITs for what you're saying. Lets you push the amp a bit harder when you want, and then when you back off the guitar volume just a little you're into Mothers Milks territory. The ITs have a bit more body than the stock TexMex pickups that are in there (I suspect MMs behave quite a bit like those). I did like the stock pickups, but I had ITs already, and it was a "marriage made in heaven" when I gave them a go.
If it's a 50s, with the maple neck, mine's got a lovely honk to it. I suspect that MMs, or even ITs, would be a little bright in there for my tastes. I actually prefer Apaches in it myself - makes it more "rock" - but I have another strat that needs the Apaches, so it has Sultans at the moment. These make it more refined, but I can still get Rory/etc with it. I tend to use this guitar to "take me elsewhere" usually, though, as I've been playing rosewood board strats for years and this is a bit different, it suggests other styles to me.
On the humbuckers, not much experience with PRS (well, none! :lol:), but I do reckon that Mules is where you want to head.
Welcome to the forum :D