That picture looks like a single coil-sized humbucker though – possibly a Seymour Duncan JB Jr.
Back on topic, I think the middle pickup alone is an underrated position (including by me, as I rarely use it). On a Strat, as you would expect, it's a pleasing halfway house between the neck and bridge sounds.
But like tekbow said, I like them best in combination with the neck and bridge pickups on a Strat.
Ibanez wiring usually splits the humbuckers in positions 2 and 4 of the switch so you can get somewhat Strat-like tones (an approximation of the Hendrix Little Wing tone, for example). If you were going for BK humbuckers, I bet the VHII would work well here. But I can't tell you for sure, because mine has 2-conductor wiring.