I have a Fender American Series HSS. I was disappointed by the pickups and the S1-switching didn't add any juice for me. Took it out, rewired it to bridge, autocoilsplit on the fourth position, middle, middle-neck, neck. CTS-pots and clothwire. Ready to tock.
I got a VHII and Mother's Milk in that one. It works with the rosewood fretboard, taming the bright topend of the MM's. They sound superb, quite woody and glassy. Genuine early sixties-tones. For you guitar I would IT's bec of the maple neck.
My custom swampash strat (MXG, made by Patrick Eggle), has a Crawler and IT's. Like Elliot says they are a sort of overwound MM's. Fuller, more grit, but they clean up very nice and you can squeeze some nice Chili Peppers-tones out of them.
Btw, the VHII splits good with the middle-MM, but the splitted Crawler and middle-IT does a better job for me.