Hello. I recently bought an Ibanez RG2550E, one of the best playing guitars I have ever tried! As with all my other guitars, I will exchange the pickups for Bare Knuckles to make the guitar "mine" (the Dimarzios are quite decent, but they ain't no Bare Knuckles!). The bridge-pickups sounds a little bit flubby, and is maybe the least tight pickup I have heard, while the neck is a little bit low output.
Mr Ben French at Bare Knuckle recommended me a set of Nailbombs (ceramic bridge) and a Trilogy Suite in the middle. However, there is a guy who sells a set of (used) Painkillers for a little bit over half the price of a new set...
The guitar will be used for Metallica, Racer X and similar (pretty technical stuff) and I bought the RG to be my metal/shred guitar. It is important that the bridge pickup is tight, raw and powerful, yet useful for leads even though I will use the neck mostly for them fast sweep/legato licks. The neck has to be smooth and fluid, yet articulate and not muddy. My amplifier of choice is the Mesa Boogie Mini Rectifier. I have a Gibson Les Paul Standard with a set of Cold Sweats, and I want something hotter for the RG.