Well, for the record, i just did it and it worked quite well. i left the tuner tilted like that because of the screw hole of the one i ended up getting and also because i thought it looked kind of wonky in a cool way?
either way it's a complete success for that guitar, and tuning and managing the low F is much easier, almost tempted to treat my low B as well, but like PhillyQ said i guess there's only so much wood you can remove before it starts being a problem.
putting the string requires you to be a bit careful, more than with regular tuners, you really have to wind the string down. string height bar like on ibanez guitars might help with that however.