Nah.
Orange take the reliability of the valves they use very seriously. I've heard their valve amp designer talking about such things in person. They used JJ ECC803S at one point because they are easy to get and sound good and are pretty reliable, but I know they started using the JJ ECC83S because it is even more reliable, better for combos because combo's played loud transfer more vibration into valves, and the trade off in tone was acceptable given those benefits. I'm not sure what they use for output valves but I'd bet they have put in something reasonable and not just cheap chinese guff.
If you want to figure out if its the preamp or power amp valves making the noise, depending on the FX circuit (if it's insert and not parallel) you should be able to break the connection from the preamp to the power amp. If you still get a noise, it's something after the FX return. Possibly the FX retun stage, the PI or the output valves.
that said. I find lots of amps make little pops but I don't sweat it.
How long have you had the amp? Ever changed the valves?