How big are the venues you're playing? I mean i see 2 options with this, and if i've got this wrong then please let me know as i have no experience with wireless, but:
1) system goes after your pedal board broadcasting to the receiver going into the amp, in which case, you're still tied to your pedal board by a cable and, in my eyes you've got a disconnect between any OD/FUZZ/Dist before it hits the front end of the amp.
2) you have a belt or strap transmitter from the guitar broadcasting to a receiver in front of the pedal board, in which case you'll still have a fairly long cable run from the board to the amp (presuming your board is front on the stage and your amp is toward the back)
either case to me seems like it's defeating the purpose of having the wireless?
When i think of wireless, i think of guys doing stadium or big hall gigs where they move around a lot. and a lot of the time those guys effects are backstage being operated by their tech with the exception of maybe a wah or something (am thinking the likes of dream theatre here) and it's all been combined in a custom built effects setup.
Like i said, i think if you're talking "straight in", guitar, trans/rec, amp, then it's not so much an issue. but if you got a big board of in the front stuff, especially with old school effects then it needs to stay direct.
In some things i call spraff, like TS9 vs 808's and their respective chips etc, but i'm quite suprised to learn how superstitious i can be about other things, i mean as i said, it's all just currents and voltages right?