Might be blasphemy but

[MatchooW]

I'm thinking of changing the pickups in my PRS Custom 24, they're lovely pickups but are just lacking for the style of music I play. Think modern Machine Head sorta sound, drop B too.

I use a Mesa Mark V with a Maxon OD 808, through a rectifier 4x12.

What pickups can you recommend me? I'd still like it to be fairly versatile and nice sounding throughout each of the 5 switching positions. 

Thank you for your time.

[Duck2587]

Aftermath or miracle man all the way. Especially with your low tuning.

[MatchooW]

I've played some Mayones' with Aftermaths and they sound too hollow for me, I actually have a Miracle man in my Charvel, I'll have to have a play around on that when I get chance.

[Dave Sloven]

Maybe have a look at the Cold Sweat and Rebel Yell.  They are both bright and tight, could be what you need.  Both should also sound good through your Mesa.

[ericsabbath]

definitely miracle man

maybe ceramic nailbomb or painkiller for the burn my eyes type of tone

[Telerocker]

When Aftermaths are too hollow for the OP, would the Miracle Man not be too scooped?