Yes, you will have to adjust the intonation. Even when you are going from thinner to thicker strings without changing tuning you have to set it up slightly.
The good thing is that you don`t need any 'expert' to do this. What you need is flat screwdriver to work on saddles and tuner. That`s it.
I presume you won`t be messing with truss rod, bridge height. Intonation is really simple and straightforward job.