I've just seen a post for a very similar problem, but thought a mine merits a new topic due to the complexity...or should I say my fussiness haha.
I'll start by saying, like the other post, I play a ESP Eclipse. Hardtail and 24.75" scale. I've recently acquired quite a few guitars and thought it best to try and fine tune (no pun intended) my string gauges.
I grew up playing my trust old Epiphone Les Paul and LTD Eclipse later on, and I always bought Ernie Ball Skinny Top Heavy Bottoms (10-52). I used these strings originally when playing Standard D and Drop C. But as I got into more music, I found myself tuning up to standard quite a lot, so these became my good-to-go strings. Something I did find though was: the tension of the bottom 3 strings I preferred in E Standard as they felt the were more secure and let my pick fast without flubbiness. At the time the top 3 (10-17) felt tighter in a certain sense, but my fingers developed strength and I now find myself preferring 10-52 for E Standard on 24.75" as it just feels perfect. Only think I could wish for is maybe a heavier E String for when I drop to Drop D...but it's liveable.
Even though I still use this Guage to go to Drop C/D Standard, with the new guitars I've got, I'm wanting to take it to the next level and have a guitar especially set up for Drop C at all times. Whilst the guitar will be set up as Drop C permanently, I still want the bottom string to be able to be tuned up to D Standard without causing any damaging stress. But preferably I want the feel of something like the 10-52, but tuned a whole step down, with a heavier bottom string for better tension.
I don't mind getting a 6 string set and then replacing the bottom string. I'm just looking for guidance at the moment
I just thought I'd add, when I play my MusicMan JPXI (25.5"), I find the top strings a tad bit too tight. Just so you have a few ideas on what I'm looking for.