Like other I prefer the S2 series over the more expensive "dentist guitars". It is a small thing, but I just wish the single cut didn't have a flat top. It just looks wrong that way, it should be carved.
I know what you mean, but in terms of playing comfort I find the SG-influenced contouring more comfortable than an LP-style carved top. Not a sharp edge anywhere. And on the S2 Singlecut Standard (as opposed to the maple-topped S2 Singlecut), the contouring complements the scratchplate really well.
That model is really, really growing on me....! 
Yep, I have a dirty great bruise on my right fore-arm from recording a bunch of guitar parts with my Les Paul last Sunday... Now I remember why I used to wear big sports-bands on my wrists/fore-arms (a la Mark Knopfler) when I was playing live!!

Tele just as bad... SG shape much more comfortable, but a strat's the best. (AND you can play a strat slumped on the sofa!

)
Out of that bunch, if they did the Standard 22 in the same configuration as the Single Cut (just a slight tweak to the scratch-plate for the top horn), I'd be starting to feel stirrings...