For me, I hate neck humbuckers in the sense they never seem to have that top end I get from the bridge. Which leads me to believe, it's not the pickup I dislike, it must be related to the higher tension near the bridge. I like the neck slot purely as it sounds more "tubular". But it lacks the cut from the bridge. Bridge pickups are normally more rounded to compensate for that "sharper" tone the bridge provides. Kind of the same way a fatter/warmer pickup is more suited to a brighter guitars, and how something like the Emerald or Cold Sweat is suited more to a darker guitar.
Now building on this point (no pun intended), there's many players out there hat use DiMarzio pickups that are highly suited to the bridge, in the neck spot. But you find 8/10, they're playing pretty bright guitars to begin with.
My logic from this is if you hate how warm a neck pickup is, in something, let' say, a Les Paul... putting the bridge pickup in the neck is going to completely take you in the wrong direction.
But as time has shown, you'd be surprised how often these rules have been broken. Seymour Duncan, himself, strongly advises against using the Alnico II pro neck in LP type of guitars. Saying it's way too warm. But also says that Slash, gets away by how bright his amp is. If anyone has played his choice of Marshalls, especially the AFD model, you will know it is "extremely" bright! So it adds that top end. The pickups purely provide that low output, organic feel. Whilst the amp provides the distortion/overdrive. And gives what is a very warm pickup, that added harmonically rich tone.
I think this leads o the next point: I'd say players are divided into the low output pickup users, who use the amp to provide the overdrive and distortion; and the players who use how output pickups, that hit amps hard and provide similar tone. The Rebel Yell pickup provides a lot of harmonics, whereas you might play a pickup that is very warm into an amp like the Marshall AFD, and it's the amp that provides the harmonics due to the EQ of it/
So for me personally, I prefer bright neck pickups. But if you fall into the other category where you use the amp for the brightness, you could definitely get away with a bridge pickup in the neck. But in this situation, I'd personally choose this if you like the feel of the pickup.
Hope this helps. I'm no GURU, and my opinions may be completely off. But this is what I've found from personal experiences. But normally high output pickup users use the pickup to hit the amp. So I'd use a bright mp if you want a hi output bridge pickup in the neck. But hey...people use the Dimarzio Tone Zone in the neck. So I say try it. My ears are different to yours :)
