I swapped the stock 498T/490R in my 92 Les Paul custom for Holydivers. 498T has more bite, is more aggresive than HD, but despite being more mid-focused, HD has more clarity. The 498T sounded as if the amp was in the next room (obviously going to extremes). Besides the clarity issue, I was looking for the fuller mids of the HD so it's perfect for me.
About the neck... the same about clarity (compared to 490R). I have another LP with Mules. Comparing both necks (HD and Mules), they are closer than related bridge pickups. If I was looking for versatility, I would go with mule in the neck, but HD neck is great for playing softer styles and great for shredding.