I've just put them on my Mule eqipped Eclipse and although they are a little less hairy at the top end, they do suit the Mules quite well - a little less bright at the extreme top end but a little bit more emphasis and "grind" in the mids. I've just ordered another set with the remainder of my points to try on my Nail Bomb equipped guitar and expect them to also be quite a good match.
Edit - have now strung my Nail Bombed Eclipse with these and they really work well together, with the NYXLs making the most of the Nail Bomb's gnarly character while also taming its hairyness.
Edit Edit - now changed my Nail Bomb equipped Eclipse back to standard EXLs, I found the NYXLs tamed the Nail Bombs too much and took off the "hairy sheen" that the NBs are infamous for. Now I'm back to EXLs and the NBs sound bright and hairy again! So, great for the Mules, not so great for Nail Bombs (unless you're trying to tame them a little) and Crawlers.
So, my first impressions of these new strings are that they have a little less output right at the top end of the frequency range but a little more in the mids and upper mids. As a result they seem to work well with bright pickups but less well with darker pickups that already have less output at the top end. It's also too early to tell how they will wear, so I'll continue playing them for a while before I consider this aspect.