I have an LTD MH1000 with an alnico Nailbomb bridge and a VHII neck, replacing EMG's and an Ibanez FRIX6 with a Holydiver bridge and an Emerald neck, also replacing EMG's. The holes for the shafts were slightly smaller, but easy enough to carefully widen a tiny bit, to make room for 500k CTS pots.
I recently replaced the 498T/490R in my Les Paul with a Riff Raff bridhe and Mule neck, and it dawned on me how much I appreciate the tone of lower output humbuckers, which is why I want another set of lower output pickups in my collection of guitars.
Higher output pickups have a tendency to sound dark, I know this from comparing the Nailbomb and Holydiver to the Riff Raff, despite the the Holydiver having a very nice high end.