Both pickups would work so well, it's a tough choice. Like the tshirt, life is full of important choices....
There's also VHIIs, Black Dogs, and the Abraxas (Mule meets Rebel Yell?), to consider.
I have a LP loaded with a Rebel Yell set. I can highly recommend them if you want a brighter sound which is best with a little bit of gain on them. They're great for the slightly heavier side of rock where you want something that really screams... just think of the song Rebel Yell. They can clean up quite nicely and you can add a lot of gain and play thrash on them as well.
If you play mostly cleaner, then you'll love the Mules for their cleaner tones. A lot of people seem to be going Black Dog bridge and Mule neck for a slightly more aggressive bridge tone too which looks very appealing to me.