My understanding was that 250K pots in strats are used to compensate for overly bright single coils, but to keep treble content in HB guitars, it's better to use 500K pots.
I mean that's just what I heard, it doesn't mean that I actually understand why, so someone more capable should comment.
If that was true however, I would be wondering whether the mules might lose some of their clarity/crispness when used with 300K pots.