Crackling and popping is usually associated with power tube wear.
this is off the MESA site and is always useful;
Signs of Wear
Power Tubes:
• Low end response is not as clear and distorts earlier.
• You turn your amp’s master volume up to hear the level that
you are used to hearing.
• Eventually you will hear 'crackling' 'popping' sounds, often accompanied by:
• 'Swelling' volume levels.
• Buzzing.
Preamp Tubes:
• Hissing, 'shooshing'.
• Sputtering, 'grumbling'.
• Microphonic squealing (feedback type sound).
• Loss in signal in one or more modes of the amp (channel, reverb, fx-loop).