Firstly thanks guys for the responses :D
Ok i have thought about both Orange and Matamp, but living in Northern Ireland is the problem, i haven't really had a chance to play through either. I am looking at going for a Marshall. Played the Vintage Modern and i thought it was way too muddy and the JVM is way too modern sounding! I dont use alot of gain, just alot of power amp oomph!!
Guitar wise, some good suggestions guys and its good to see so many people with different views!!!
To be honest i couldn't see myself playing anything else other than gibson, or a guitar that will deliver as close to that sound as possible.
One question, i love ES335's, but does anyone think it could handle the detuning a whole step and serious volume without feedbacking? (in local gigs i can play a marshall 100 watt head through a 4x12 with greenbacks at 7 on the master volume no problem, we have generous soundmen over here!! :D) Im looking for that big sound, where chords ring out with lots of clarity making each chord tone come through, not just the root note!