Acoustically a hollow/chambered body seems to emphasise highs and lows more than a solidbody. I haven't played many chambered guitars, but I have a Thinline Tele and I used to own a Hamer Artist - both tend to sound a bit boomy on the bass strings and a bit harsh/snappy on the treble strings.
I'm guessing here, but I think high output pickups might emphasise the extra bassiness to the point that it becomes really boomy and mushy. And also perhaps there's more likelihood of problematic feedback?