When I'm playing guitar I either use a 2x12 open-backed or 4x10 opened back combo.
Ideally I mic the amp for a better spread in the mix (although we don't always do this), however for the type of music I play I don't drive the amp hard and play fairly clean.
The only environment were I play classic pub rock music I actually play bass, although I usually do the sound mixing too.
Here we use 2x12 open backed and 1x12 open back combos close miced.
I suspect most of the rockers here would be horrified by the brands of gear we use for this, but (although I say so myself) the results are very good, although we are helped by the fact our guitar player is exceptionally good....