I don't know... with a high-quality PCI card there shouldn't be any noise coming from the rest of the computer. I have an EMU 1212M, it's a two-card setup. It has its own FX processors, zero-latency monitoring, mastering-grade AD/DA converters and a very good patchbay/mixer interface (Patchmix DSP) for signal routing, level control, pan, EQ, inserting effects, send/return, monitoring etc. I think it's in the price range you're looking at because when I was planning to buy a sound card, the ones mentioned in this thread were on my list. :) EMU makes very good stuff.