The calibrated set in my PRS Custom 24 w/rosewood neck really made a difference to it. Bridge has lots of definition (presence, I suppose, rather then treble), tight bass but still a very rounded tone. Neck I don't use much but has much the same characteristics. Good combination of fatness & clarity, blows the PRS HFS/VB set out of the water as the CS set was Tim's replacement recommendation. I'd love to hear them in something like a Les Paul!
I've not tried the Holy Diver. That's interesting me though as I've got a 7 being built and the current front-runner for p/us are the Cold Sweats. If the HDs are fatter without losing too much definition then I may be tempted that way although you can't lose with the CS. Very versatile....