Nice idea Hunter :) Hopefully my thoughts won't be too controversial. I'll stick to live setting, since i'm experimenting more at home.
Thick 11-48,49,50 strings, not ernie ball - hurt my fingers a bit, and hopefully help me to play a bit more passionately. (at home i also like 9s)
Flying V or Steinberger GP shape - looks good on stage, hopefully giving the impression of good tone/ability to the audience - its a bit fake i know, but i think it works. i think hard maple through neck with ceramic pickups gives the gwEm sound ;)
Absolutely no digital equipment in my signal chain (though that might change one day). Live I swear by sansamp gear.
Vintage or modern high gain pickups - no vintage hot stuff
Also, its not really a secret but I think the only pickups which sound ALOT different to the typical listener are EMG vs passive. Only active pickups give the active tone.
I have a 'lucky cable' too, it probably sounds like arse, but i used it for years ;)
I've tried alot of picks, but i'm used to dunlop tortex 0.88mm. i could probably get used to different picks, but i find it hard to use anything else. its firm enough, but not too thick so it breaks the strings. when i was a young punk, i snapped strings all the time at home. i heard phil campbell from motorhead used this picks so not knowing anything else i tried them. seemed to help at the time :)
edit:
you see there quite alot of superstition in my tips... mmm, i never thought about that before. not much of substance people can take here - unless its to be absolutely comfortable and trusting in ones equipment. which is a really important thing actually