i think you need a feel and understanding of what genre or whatever you're trying to pull off. Ive watched my friends who are more technical than me try and copy what i do and it sounds aweful. not that im aweful sounding to being with, there doesnt seem to be anything organic about they way they go about playing.
i dont play about with pick choices, or changing strings every 5 mins. i think there comes a point when you know what sound you want, and you know how to drive amps etc... and that knowledge makes it easier.
Ive turned up to gigs where ive had to string, tune and set up an amp for the guitarist for a support band because he had NO idea how to do any of that, but he could just about play. thats it! crazy!
i think there must be a difference between people who listen to, break down, and analyse music, rather than those who just consume it and carry on.