Yes. I'm using it with a single channel Chadwick set for a real nice clean clean. It comes surprisingly close to my Revolution in sound and feel, but the cool thing is I can scale it back volume-wise a little on the box and just leave my clean settings alone on the amp.
On the Rev, I'm using a Krankshaft (tube screamer) on top of the gain channel to boost it for leads. I set up the dirt channel to have "just enough" gain for rhythms.
I've found that this is the best way to get a less "metal" and more "rock" tone out of the Rev. I love it's aggressive tone but don't care for some of the buzzy metal clips that are around.
With just a little time on the Distortus Maximus, I can tell you are correct. Works best with clean clean.
The Krankshaft is just the opposite. Awesome at taking the gain channel and kicking it into sweet, creamy, squeally lead tones, but I don't like it much on its own on the clean channel.
