Hi James, the Florentine might sound good with Mules. I have them in 2 semi hollow guitars, one has A4's (my 60's 335), and the other has A2's (a Raven West PRS hollowbody copy). If the Florentine is a bit bright (the ones I tried at NAMM were), then the A2's help tame it a bit, though with the A4's in the 335, I can get the Clapton Cream Crossroads tone.