I'm in doubt between the ISP and MXR myself. I like MXR in general (my pedalboard is fully MXR, except for the power supply and tuner) so I suppose the Smart Gate would be a no-brainer. But they have that new one, which is slightly cheaper yet seem to do more. And the ISP is reputed to be the best noise gate out there.
I used the NS2 for years, because I didn't know any better. Talk about a tone killer... :?