Putting the Tubescreamer type pedal in front will dramatically tighten it up, though you are going to loose some of the low-end.
I recommend the Maxon OD808 RI or the Barber Driver Direct as far as the od pedals go. There are many good ones out there, but I like these in particular.
As far as pickups, it kind of depends on the tuning. The Rebel Yell is quite awesome if you want to go with Alnico V. If you want to go in your face kind of sound, Painkiller or Warpig.