If the Rebel Yells are also quite aggressive, an Abraxas set could be just the ticket as they're extremely versatile and as a hot version of the Mules, will suit a Les Paul very well. I'd also like to put forward a set of Emeralds as they also work very well in Les Pauls, aren't too hot and offer some fantastic tones.
As far as some pickups being too middy is concerned, I wouldn't worry too much about it as in my experience, the EQ charts tend to exaggerate what's there but the reality is invariably more balanced. My Holydiver is supposed to be very mid-focused but I put it into a very middy guitar and I still boost the mids on my EQ because the reality is that it's a lot more balanced than you think. By the same token, Cold Sweats are supposed to be very bright and while they are a bright pickup, it's nothing like as extreme as the website suggests.